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I noen studier har opptil 30% av pasientene som opprinnelig reagerte vist tap av krampestillende aktivitet, ofte innen 3 måneder etter administrering. I noen tilfeller kan dosejustering gjenopprette effekten.Informer pasienter og omsorgspersoner om at potensielt dødelige additiveffekter kan

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